Alzheimer’s disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease. In hopes of discovering new targets for potential Alzheimer’s treatments, MIT researchers have performed the broadest analysis yet of the genomic, epigenomic, and transcriptomic changes that occur in every cell type in the…
Your brain is powered by 400 miles of blood vessels that provide nutrients, clear out waste products, and form a tight protective barrier — the blood-brain barrier — that controls which molecules can enter or exit. However, it has remained unclear how these brain vascular cells change between brain regions, or in Alzheimer’s disease, at single-cell resolution. To address this…
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